COMBINATION OF FARNESYL-TRANSFERASE INHIBITION WITH KRAS G12D TARGETING BREAKS DOWN THERAPEUTIC RESISTANCE IN PANCREATIC CANCER

Combination of farnesyl-transferase inhibition with KRAS G12D targeting breaks down therapeutic resistance in pancreatic cancer

Pancreatic adenocarcinoma is one of the deadliest forms of cancer with no effective therapeutic options.A KRAS mutation can be found in up to 90% of all pancreatic tumors, making it a promising therapeutic target.The introduction of new KRAS inhibitors has been a milestone in the history of KRAS mutant tumors; however, therapeutic navy blue maang t

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A 13-LOX participates in the biosynthesis of JAs and is related to the accumulation of baicalein and wogonin in Scutellaria baicalensis

Although baicalein and wogonin contents in Scutellaria baicalensis, a traditional Chinese herb, are known to be regulated by jasmonic acid, the exact mechanism by which jasmonic acid regulates the accumulation of baicalein and wogonin remains unclear.In this study, we discovered SbLOX3, a gene encoding 13-lipoxygenase from the roots of S.baicalensi

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